Melanotan II (MT-2)

Melanotan 2 was developed from work on alpha-MSH at the University of Arizona, where researchers sought a more stable, longer-acting analogue of the native hormone for studying pigmentation biology. The result is a cyclic peptide that activates several melanocortin receptors rather than one.

That broad receptor activity is precisely what makes MT2 a useful research tool: it allows investigators to probe the melanocortin system, of which melanogenesis is one well-studied output. In the literature, the compound is examined for how melanocortin-receptor engagement relates to pigment production in cellular and animal models.

Compared with more receptor-selective analogues, MT2's non-selectivity makes it a reference point for distinguishing which melanocortin pathways drive which observed effects — a recurring question in Canadian pigmentation-research groups.

• Skin Pigmentation Research — MT2 is studied for its relationship to melanogenesis in pigment-cell models, attributed to melanocortin-receptor activation.
• Melanocortin Receptor Pharmacology — As a non-selective agonist, it serves as a tool for characterising receptor-subtype contributions.
• Appetite & Energy Signalling Research — The melanocortin system's role in energy regulation is a study domain in which MT2 appears.
• Comparative Analogue Studies — It is used as a reference against more selective melanocortin compounds.

• GHK-Cu — A copper tripeptide studied within adjacent skin-research contexts.
• PT-141 — A melanocortin-receptor peptide derived from the same research lineage.
• Wolverine Stack— A proprietary blend within the healing/recovery research domain.

Where can I buy melanotan 2 in Canada for research?

Melanotan 2 is supplied to Canadian research buyers as a lyophilized, research-grade peptide, HPLC-verified to ≥99% with MS-confirmed identity and a batch-specific COA.

How is melanotan 2 different from PT-141?

Both act on melanocortin receptors, but PT-141 is a related downstream compound studied more for melanocortin signalling in behavioural models, while MT2 is studied more in the context of pigmentation and broad receptor activity.

Is melanotan 2 naturally occurring?

No. It is a synthetic, cyclic analogue engineered from the natural hormone alpha-MSH for improved stability in research settings.

How are purity and identity verified?

Each batch is HPLC-verified (≥99%) and MS-confirmed, with a batch-specific COA. Material is lyophilized and stored at 2–8 °C, protected from light, and Canadian researchers receive lot-matched documentation.

⚠️ For research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.