TB-500

• Form: Lyophilized peptide
• Net per vial: 10 mg (filled to approximately 104% of label)
• Purity: ≥99% (HPLC-verified)
• Identity: MS-verified (per COA)
• Storage: 2–8 °C, protect from light
• Formula / M.W.: C₂₁₂H₃₅₀N₅₆O₇₈S / 4963.44 Da
• CAS: 77591-33-4

TB-500 corresponds to a short, active region of thymosin beta-4, the protein responsible for much of the cell's regulation of actin. Where many repair peptides act on growth-factor signalling, TB-500's research interest centres on the cytoskeleton itself — the machinery cells use to move, divide, and reorganise during repair.

The parent protein, thymosin beta-4, has been studied across regenerative biology for decades; TB-500 gives researchers a synthetic handle on its actin-binding activity in a defined, reproducible form. In published work, that activity is linked to cell migration and to the formation of new vasculature.

Set against adjacent repair compounds, TB-500 is frequently chosen when a study's focus is cell motility and remodelling rather than vascular signalling alone — which is why it so often appears alongside, and is compared with, BPC-157 in Canadian repair research.

• Cellular Migration — TB-500 is studied for its role in promoting the movement of cells during tissue remodelling, attributed to its actin-binding activity.
• Tissue Repair — Research has examined the fragment within models of soft-tissue and muscle repair.
• Angiogenesis — The literature investigates its association with new blood-vessel formation.
• Cytoskeletal Research — s a thymosin-derived tool, it is used to probe actin dynamics specifically.
• Anti-Inflammatory Modulation — Cell-based and animal studies have measured reductions in inflammatory cytokine expression and modulation of NF-κB signaling, framing TB-500 as a candidate for investigation into inflammation-coupled tissue repair.

Researchers working with TB-500 often investigate it alongside:

• BPC-157 —  repair-focused peptide frequently studied alongside TB-500 for comparison.
• GHK-Cu — A copper tripeptide examined in remodeling research.
• Wolverine Stack — A proprietary research blend within the tissue-repair domain.
• Retatrutide (GLP-3) — TB-500's cardiac-research literature complements cardiometabolic designs incorporating Retatrutide.

Are TB-500 peptides available for research in Canada?

Yes. TB-500 peptides are supplied to Canadian research buyers as lyophilized, research-grade material, HPLC-verified to ≥99% with MS-confirmed identity and a batch-specific COA.

How is TB-500 different from BPC-157?

TB-500 derives from thymosin beta-4 and is studied mainly through actin-binding and cell-migration mechanisms, whereas BPC-157 derives from a gastric protective protein and is studied with more emphasis on angiogenesis and growth-factor pathways.

Is TB-500 naturally occurring?

It is a synthetic fragment modelled on a region of the natural protein thymosin beta-4; the supplied peptide is manufactured rather than extracted.